Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals.

ABSTRACT:

Objective

Most individuals with two or more islet autoantibodies progress to clinical type 1 diabetes. However, in some individuals, autoantibodies are subsequently lost. Here, our objectives were to determine the frequency of autoantibody loss (reversion) in multiple-autoantibody-positive individuals and to determine the association between reversion and progression to clinical disease.

Research design and methods

We analyzed multiple-autoantibody-positive individuals participating in TrialNet's Pathway to Prevention Study for reversion and determined the effect of reversion on progression to clinical disease using a Cox regression analysis.

Results

Of 3,284 multiple-autoantibody-positive subjects, reversion occurred in 134 (4.1%) and was associated with reduced inci

SUBMITTER: So M 

PROVIDER: S-EPMC7085807 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature