Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.

ABSTRACT: Voltage-gated sodium channels (Na_v) are essential for electrical signaling in the nervous system. They are also the primary targets of several classes of insecticides including pyrethroids. There is only one sodium channel gene in most insect species, whereas mammals possess at least nine sodium channel genes. Extensive alternative splicing and RNA editing of sodium channel transcripts have been documented in many insect species. However, the functional consequences of these post-transcriptional events have been evaluated only in DmNa_v and BgNa_v from Drosophila melanogaster and Blattella germanica, respectively. In this study, we isolated 41 full-length cDNA clones encoding 34 sodium channel (NlNa_v) variants from a major rice pest, the brown plan

SUBMITTER: Sun H 

PROVIDER: S-EPMC7085919 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature