DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics.

ABSTRACT:

Background

Response to inhaled corticosteroids is highly variable, and the association between DNA methylation and treatment response is not known.

Objective

To examine the association between peripheral blood DNA methylation and inhaled corticosteroid response in children with persistent asthma.

Methods

Epigenome-wide DNA methylation was analysed in individuals on inhaled corticosteroids in three independent and ethnically diverse cohorts-Childhood Asthma Management Program (CAMP); Children, Allergy, Milieu, Stockholm, Epidemiology (BAMSE); and Genetic Epidemiology of Asthma in Costa Rica Study (GACRS). Treatment response was evaluated using two definitions, the absence of emergency department visits and/or hospitalizations and the absence oral corticosteroid use whi

SUBMITTER: Wang AL 

PROVIDER: S-EPMC7085934 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature