Longitudinal course and risk factors associated with psychosis in bipolar youths.

ABSTRACT:

Objectives

To compare the longitudinal clinical course of youths with bipolar disorder (BD) spectrum with lifetime (past, intake, and/or follow-up) psychosis (BDP+) to youths with BD without lifetime psychosis (BDP-). Also, to identify risk factors associated with increased risk of first onset of psychosis during prospective follow-up.

Method

Bipolar disorder youths (BDP+ = 137, BDP- = 233), aged 7-17 years old, were followed on average every 7 months for 11.7 years and were evaluated using standardized instruments. Data were analyzed using linear and generalized linear models for the full sample, as well as for youths who developed first period of psychosis (n = 55).

Results

After adjusting for confounders, BDP+ youths with one, and in particular ≥2 lifetime psychoti

SUBMITTER: Shalev A 

PROVIDER: S-EPMC7085953 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature