Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.

ABSTRACT: Exposure to fluoride (F) or arsenite (As) through contaminated drinking water has been associated with chronic nephrotoxicity in humans. Autophagy is a regulated mechanism ubiquitous for the body in a toxic environment with F and As, but the underlying mechanisms of autophagy in the single or combined nephrotoxicity of F and As are unclear. In the present study, we established a rat model of prenatal and postnatal exposure to F and As with the aim of investigating the mechanism underlying nephrotoxicity of these pollutants in offspring. Rats were randomly divided into four groups that received NaF (100 mg/L), NaAsO₂ (50 mg/L), or NaF (100 mg/L) with NaAsO₂ (50 mg/L) in drinking water or clean water during pregnancy and lactation; after weaning, pups were exposed to th

SUBMITTER: Tian X 

PROVIDER: S-EPMC7085982 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature