Influence of sulfonated and diet-derived human milk oligosaccharides on the infant microbiome and immune markers.

ABSTRACT: Human milk oligosaccharides (HMOs) promote the development of the neonatal intestinal, immune, and nervous systems and has recently received considerable attention. Here we investigated how the maternal diet affects HMO biosynthesis and how any diet-induced HMO alterations influence the infant gut microbiome and immunity. Using capillary electrophoresis and MS-based analyses, we extracted and measured HMOs from breast milk samples and then correlated their levels with results from validated 24-h diet recall surveys and breast milk fatty acids. We found that fruit intake and unsaturated fatty acids in breast milk were positively correlated with an increased absolute abundance of numerous HMOs, including 16 sulfonated HMOs we identified here in humans for the first time. The diet-derived mon

SUBMITTER: Quin C 

PROVIDER: S-EPMC7086044 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature