Prediction of rapid amyloid and phosphorylated‐Tau accumulation in cognitively healthy individuals.

ABSTRACT:

Objective

To test the hypothesis that among cognitively healthy individuals, distinct groups exist in terms of amyloid and phosphorylated-tau accumulation rates; that if rapid accumulator groups exist, their membership can be predicted by Alzheimer's disease (AD) risk factors, and that time points of significant increase in AD protein accumulation will be evident.

Methods

The analysis reports data from 263 individuals from the BIOCARD and 184 individuals from the Baltimore Longitudinal Study of Aging with repeated cerebrospinal fluid (CSF) and positron emission tomography (PET) sampling, respectively. We used latent class mixed-effect models to identify distinct classes of amyloid (CSF and PET) and p-Tau (CSF) accumulation rates and generalized additive modeling to investiga

SUBMITTER: Koychev I 

PROVIDER: S-EPMC7086102 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature