Proteomic comparison of selective breeding and growth hormone transgenesis in fish: Unique pathways to enhanced growth.

ABSTRACT: In fish used for food production and scientific research, fast growth can be achieved via selective breeding or induced instantaneously via growth hormone (GH) transgenesis (GHT). The proteomic basis for these distinct routes towards a similar higher phenotype remains uncharacterized, as are associated implications for health parameters. We addressed this knowledge gap using skeletal muscle proteomics in coho salmon (Oncorhynchus kisutch), hypothesising that i) selective breeding and GHT are underpinned by both parallel and unique changes in growth systems, and ii) rapidly-growing fish strains have lowered scope to allocate resources towards immune function. Quantitative profiling of GHT and growth-selected strains was done in comparison to wild-type after injection with PBS (control) or P

SUBMITTER: Causey DR 

PROVIDER: S-EPMC7086150 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature