Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.

ABSTRACT: Geographic patterns in human genetic diversity carry footprints of population history and provide insights for genetic medicine and its application across human populations. Summarizing and visually representing these patterns of diversity has been a persistent goal for human geneticists, and has revealed that genetic differentiation is frequently correlated with geographic distance. However, most analytical methods to represent population structure do not incorporate geography directly, and it must be considered post hoc alongside a visual summary of the genetic structure. Here, we estimate "effective migration" surfaces to visualize how human genetic diversity is geographically structured. The results reveal local patterns of differentiation in detail and emphasize that while genetic sim

SUBMITTER: Peter BM 

PROVIDER: S-EPMC7086171 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature