Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes.

ABSTRACT: Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico's Indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions of private genetic variants of functional and biomedical relevance. Here we have targeted the coding fraction of the genome and characterized its full site frequency spectrum by sequencing 76 exomes from five Indigenous populations across Mexico. Using diffusion approximations, we modeled the demographic history of Indigenous populations from Mexico with northern and southern ethnic groups splitting 7.2 KYA and subsequently diverging locally 6.5 and 5.7 KYA, respectively. Selection scans for positive selection reveale

SUBMITTER: Avila-Arcos MC 

PROVIDER: S-EPMC7086176 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature