Modulation of K⁺ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.

ABSTRACT: Fast N-type inactivation of voltage-gated K⁺ (Kv) channels is important in fine-tuning of cellular excitability. To serve diverse cellular needs, N-type inactivation is regulated by numerous mechanisms. Here, we address how reactive sulfur species-the gaseous messenger H₂S and polysulfides-affect N-type inactivation of the mammalian Kv channels Kv1.4 and Kv3.4. In both channels, the H₂S donor NaHS slowed down inactivation with varying potency depending on the "aging" of NaHS solution. Polysulfides were > 1000 times more effective than NaHS with the potency increasing with the number of sulfur atoms (Na₂S₂ < Na₂S₃ < Na₂S₄). In Kv1.4, C13 in the N-terminal ball domain mediates the slowing of in

SUBMITTER: Yang K 

PROVIDER: S-EPMC7086210 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature