PET Imaging of Liposomal Glucocorticoids using ⁸⁹Zr-oxine: Theranostic Applications in Inflammatory Arthritis.

ABSTRACT: The encapsulation of Glucocorticoids (GCs) into long-circulating liposomes (LCLs) is a proven strategy to reduce the side effects of glucocorticoids and improve the treatment of inflammatory diseases, such as rheumatoid arthritis (RA). With the aim of supporting the development of GC-loaded LCLs, and potentially predict patient response to therapy clinically, we evaluated a direct PET imaging radiolabelling approach for preformed GC-LCLs in an animal model of human inflammatory arthritis. Methods: A preformed PEGylated liposomal methylprednisolone hemisuccinate (NSSL-MPS) nanomedicine was radiolabelled using [⁸⁹Zr]Zr(oxinate)₄ (⁸⁹Zr-oxine), characterised and tracked in vivo using PET imaging in a K/BxN serum-transfer arthritis (STA) mouse mode

SUBMITTER: Gawne PJ 

PROVIDER: S-EPMC7086351 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature