Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.

ABSTRACT:

Introduction

Apolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation.

Methods

We tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. High postoperative plasma CRP (≥234.12 mg/L) was defined by the highest sample-based quartile. Delirium was determined using the Confusion Assessment Method and chart review, and severity was determined by the Confusion Assessment Method-Severity score.

Results

APOE ε4 carrier prevalence was 19%, and postoperative delirium occurred in 24%. The relationship between CRP and delirium incidence, severity, and duration differed by ε4 status. Among ε4 carriers

SUBMITTER: Vasunilashorn SM 

PROVIDER: S-EPMC7086383 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature