Thrombin generation in a woman with heterozygous factor V Leiden and combined oral contraceptives: A case report.

ABSTRACT: Combined oral contraceptives and factor V Leiden mutation are multiplicative risk factors for venous thromboembolism. However, it remains unknown whether this multiplicative effect is reflected in thrombin generation assays. We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin (TM) sensitivity, compared to the control population. This profile possibly reflected a high thrombotic risk. After discontinuation of combined oral contraceptives, thrombin generation and TM sensitivity improved greatly, leaving only a slightly prothrombotic p

SUBMITTER: Zermatten MG 

PROVIDER: S-EPMC7086462 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature