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Molecular detection and characterization of human gyroviruses identified in the ferret fecal virome.

ABSTRACT: The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequences of selected gyrovirus strains showed 90.7-99.4 % similarity to homologous reference gyrovirus strains. This study did not demonstrate an association between gyrovirus shedding from ferrets and the observed background disease; however, it provides evidence for genetic diversity among gyroviruses and raises the possibility that pet ferrets may transmit gyroviruses to heterologous hosts, e.g., humans.

SUBMITTER: Feher E

PROVIDER: S-EPMC7087032 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Molecular detection and characterization of human gyroviruses identified in the ferret fecal virome.

Fehér Enikő E Pazár Péter P Kovács Eszter E Farkas Szilvia L SL Lengyel György G Jakab Ferenc F Martella Vito V Bányai Krisztián K

Archives of virology 20140814 12

The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequences of selected gyrovirus strains showed 90.7-99.4 % similarity to homologous reference gyrovirus strains. This study did not demonstrate an association between gyrovirus shedding from ferrets and the o ...[more]

PMID: 25119678

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