Genome-wide association meta-analysis of age at first cannabis use.

ABSTRACT:

Background and aims

Cannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi-substance use and dependence. This study estimated the heritability of age at first cannabis use and identified associations with genetic variants.

Methods

A twin-based heritability analysis using 8055 twins from three cohorts was performed. We then carried out a genome-wide association meta-analysis of age at first cannabis use in a discovery sample of 24 953 individuals from nine European, North American and Australian cohorts, and a replication sample of 3735 individuals.

Results

The twin-based heritability for age at first cannabis use was 38% [95% confidence interval (CI

SUBMITTER: Minica CC 

PROVIDER: S-EPMC7087375 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature