Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney.

ABSTRACT: Both obesity and arsenic exposure are global public health problems that are associated with increased risk of renal disease. The effect of whole-life exposure to environmentally relevant levels of arsenic within dietary high fat diet on renal pathogenesis were examined. In this study, C57BL/6 J mice were parentally exposed to 100 ppb arsenic before conception. After weaning, both male and female offspring were maintained on 100 ppb arsenic and fed either a normal (LFD) or high fat diet (HFD). At 10 and 24 weeks of age, the offspring were sacrificed and kidneys collected. Exposure to arsenic led to an increase body-weight in LFD diet-fed female but not male mice. This response was not observed in HFD-fed female mice; however male mice showed significant increases in body weight in both As-

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7087439 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature