Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women.

ABSTRACT: A single nucleotide polymorphism (SNP) rs2853669 (A>G) in the telomerase reverse transcriptase (TERT) promoter has recently been reported in chr5:1,295,349 T>C (T349C), and was shown to be associated with increased cancer risk and poor survival in a specific population. However, at present, the role of this particular SNP with TERT promoter driver mutations and its genetic association with human papilloma virus (HPV) in patients with cervical cancer has not been determined. In the present study, the genetic association of the functional SNP rs2853669 in the presence/absence of TERT promoter hotspot mutations and HPV in patients with cervical cancer of South Indian origin was evaluated. To understand and compare the frequency of the variant allele and its risk association in different cance

SUBMITTER: Vinothkumar V 

PROVIDER: S-EPMC7087481 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature