Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study.

ABSTRACT:

Background

To investigate the association between fasting serum insulin and glucose levels with atherosclerotic plaque composition in the carotid artery. Impaired insulin and glucose levels are implicated in the etiology of cardiovascular disease; however, their influence on the formation and composition of atherosclerotic plaque remains unclear.

Methods

In 1740 participants (mean age 72.9 years, 46% women, 14.4% diabetes mellitus) from the population-based Rotterdam Study, we performed carotid MRI to evaluate the presence of calcification, lipid core, and intraplaque hemorrhage in carotid atherosclerosis. All participants also underwent blood sampling to obtain information on serum insulin and glucose levels. Using logistic regression models, we assessed the association of

SUBMITTER: Mujaj B 

PROVIDER: S-EPMC7087499 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature