Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives.

ABSTRACT:

Abstract

A series of indole-based spirothiazolidinones have been designed, synthesized and evaluated, in vitro, for their antitubercular, antiviral, antibacterial, and antifungal activities. The structures of the new compounds were established by IR, ¹H NMR, ¹³C NMR (proton decoupled, APT, and DEPT), electrospray ionization mass spectrometry, and microanalysis. Compounds bearing a phenyl substituent at position 8 of the spiro ring, exhibited significant antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at concentrations of 3.9 and 7.8 µM. Still, some of the tested compounds displayed activity on mycobacteria with MIC values of 16 and 31 µM. Four of the indole-spirothiazolidinone derivatives were found to be moderately active ag

SUBMITTER: Cihan-Ustundag G 

PROVIDER: S-EPMC7087588 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature