The future of cellular immunotherapy for childhood leukemia.

ABSTRACT:

Purpose of review

Exciting translational discoveries in recent years have brought realized promise of immunotherapy for children with high-risk leukemias. This review summarizes the current immunotherapeutic landscape with a focus on key clinical trials for patients with acute lymphoblastic leukemia or acute myeloid leukemia.

Recent findings

Chemotherapy resistance remains a major barrier to cure in children with high-risk leukemias. Immunotherapy approaches have potential to overcome this resistance given alternative mechanisms of action. Based upon preclinical activity and/or success in adult patients, recent clinical trials have demonstrated safety and efficacy of various mAb, antibody-drug conjugate, bispecific T-cell-engaging antibody, natural killer cell, and chimeric

SUBMITTER: Bonifant CL 

PROVIDER: S-EPMC7088436 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature