Genome-Wide RNAi Screen Identifies Regulators of Cardiomyocyte Necrosis.

ABSTRACT: Regulation of cellular death is central to nearly all physiological routines and is dysregulated in virtually all diseases. Cell death occurs by two major processes, necrosis which culminates in a pervasive inflammatory response and apoptosis which is largely immunologically inert. As necrosis has long been considered an accidental, unregulated form of cellular death that occurred in response to a harsh environmental stimulus, it was largely ignored as a clinical target. However, recent elegant studies suggest that certain forms of necrosis can be reprogrammed. However, scant little is known about the molecules and pathways that orchestrate calcium-overload-induced necrosis, a main mediator of ischemia/reperfusion (IR)-induced cardiomyocyte cell death. To rectify this critical gap in our k

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC7088983 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature