Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus.

ABSTRACT: Infectious bronchitis virus (IBV) is currently one of the most important pathogens in the poultry industry. The H120 and Ma5 are the only viral strains approved by the Brazilian government as the constituent of vaccines. Despite the systematic vaccination in Brazil, IBV has not yet been controlled and diseases associated with this virus have been reported in vaccinated chickens. Here, we investigated the genetic variability of H120 and Ma5 strains present in the IBV vaccines from different Brazilian manufacturers. We performed DNA sequencing analyses of the S1 spike glycoprotein gene to investigate its genetic variability and the presence of viral subpopulations among vaccines, between batches, and also in each vaccine after a single passage was performed in chicken embryonated eggs. Our r

SUBMITTER: Saraiva GL 

PROVIDER: S-EPMC7089498 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature