Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity.

ABSTRACT: Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to study neural circuits regulating sleep homeostasis. Numerous neuronal populations have been identified in modulating sleep homeostasis as well as depth, raising the possibility that the duration and quality of recovery sleep is dependent on the environmental or physiological processes that induce sleep deprivation. Here, we find that unlike most pharmacological and environmental manipulatio

SUBMITTER: Brown EB 

PROVIDER: S-EPMC7089559 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature