Confocal laser endomicroscopy detects colonic inflammation in patients with irritable bowel syndrome: a prospective study.

ABSTRACT: Background and aims  Irritable bowel syndrome (IBS) is considered to be a functional disease, but recent data indicate measurable organic alterations. We aimed to determine the presence of colorectal mucosa microinflammation in vivo via probe-confocal laser endomicroscopy (pCLE) and histological evaluation in IBS patients. Methods  This was a prospective, controlled, nonrandomized single-blind diagnostic trial performed in a tertiary institution. pCLE images and targeted biopsy of each colon segment obtained during colonoscopies of IBS patients and controls were analyzed for inflammatory changes. Biopsies were classified using the Geboes scale, and the odds ratio and overall diagnostic accuracy were calculated. Results  During the 15-month study period, 37 patients wer

SUBMITTER: Robles-Medranda C 

PROVIDER: S-EPMC7089800 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature