Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer.

ABSTRACT: Chemotherapy-related cognitive impairment and associated brain changes may reflect accelerated brain aging; however, empirical evidence for this theory is limited. The purpose of this study was to measure brain aging in newly diagnosed patients with breast cancer treated with chemotherapy (n = 43) and compare its longitudinal change to that of controls (n = 50). Brain age indices, derived from cortical measures, were compared between women with breast cancer and matched healthy controls across 3 timepoints (time 1: pre-surgery, time 2: 1 month following chemotherapy completion, and time 3: 1-year post-chemotherapy). The breast cancer group showed a significant decrease in cortical thickness across the 3 timepoints (p < .001) and a trend towards significant increase in predicted brain age e

SUBMITTER: Henneghan A 

PROVIDER: S-EPMC7089817 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature