High-Frequency Medical Cannabis Use Is Associated With Worse Pain Among Individuals With Chronic Pain.

ABSTRACT: Cannabis is widely used for chronic pain. However, there is some evidence of an inverse dose-response relationship between cannabis effects and pain relief that may negatively affect analgesic outcomes. In this cross-sectional survey, we examined whether daily cannabis use frequency was associated with pain severity and interference, quality of life measures relevant to pain (eg, anxiety and depressive symptoms), and cannabis use preferences (administration routes and cannabinoid ratio). Our analysis included 989 adults who used cannabis every day for chronic pain. Participant use was designated as light, moderate, and heavy (1-2, 3-4, and 5 or more cannabis uses per day, respectively). The sample was also subgrouped by self-reported medical-only use (designated MED, n = 531, 54%) versus m

SUBMITTER: Boehnke KF 

PROVIDER: S-EPMC7089844 | biostudies-literature | 2020 May - Jun

REPOSITORIES: biostudies-literature