A population-based resource for intergenerational metabolomics analyses in pregnant women and their children: the Generation R Study.

ABSTRACT:

Introduction

Adverse exposures in early life may predispose children to cardio-metabolic disease in later life. Metabolomics may serve as a valuable tool to disentangle the metabolic adaptations and mechanisms that potentially underlie these associations.

Objectives

To describe the acquisition, processing and structure of the metabolomics data available in a population-based prospective cohort from early pregnancy onwards and to examine the relationships between metabolite profiles of pregnant women and their children at birth and in childhood.

Methods

In a subset of 994 mothers-child pairs from a prospective population-based cohort study among pregnant women and their children from Rotterdam, the Netherlands, we used LC-MS/MS to determine concentrations of amino acid

SUBMITTER: Voerman E 

PROVIDER: S-EPMC7089886 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature