Specificity of synapse formation in Aplysia: paracrine and autocrine signaling regulates bidirectional molecular interactions between sensory and non-target motor neurons.

ABSTRACT: The formation of appropriate neural connections during development is critical for the proper wiring and functioning of the brain. Although considerable research suggests that the specificity of synapse formation is supported by complex intercellular signaling between potential presynaptic and postsynaptic partners, the extracellular factors and the intracellular signal transduction pathways engaged in this process remain largely unknown. Using the sensory-motor neural circuit that contributes to learning in defensive withdrawal reflexes in Aplysia californica, we investigated the molecular processes governing the interactions between sensory neurons and both target and non-target motor neurons during synapse formation in culture. We found that evolutionarily-conserved intercellular and in

SUBMITTER: Alexandrescu A 

PROVIDER: S-EPMC7089980 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature