The expression signatures in liver and adipose tissue from obese Gottingen Minipigs reveal a predisposition for healthy fat accumulation.

ABSTRACT:

Background

Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the pig key human pathological hepatic findings such as hepatocellular ballooning and abundant steatosis are lacking in the model.

Objectives

The aim of this study was to elucidate why these histopathological characteristics did not occur in a high fat, fructose and cholesterol (FFC) diet-induced obese Göttingen Minipig model.

Methods

High-throughput expression profiling of more than 90 metabolically relevant genes was performed in liver, subcutaneous adipo

SUBMITTER: Cirera S 

PROVIDER: S-EPMC7090036 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature