Solvent extraction and gas chromatography-mass spectrometric determination of probable carcinogen 1,4-dioxane in cosmetic products.

ABSTRACT: In the present work, a method based on solvent extraction and gas chromatography-mass spectrometry (GC-MS) has been validated for the determination of 1,4-dioxane in cosmetics. Various solvents including ethyl acetate, hexane, methanol, dichloromethane and acetone have been used for the extraction of 1,4-dioxane, among them the ethyl acetate was found to be the most efficient extracting solvent. This method has offered excellent quality parameters for instance linearity (R² > 0.9991), limit of detection (LOD, 0.00065-0.00091 µg/mL), limit of quantification (LOQ, 0.00217-0.00304 µg/mL) and, precision intra-day (1.65-2.60%, n = 5) and inter-day (0.16-0.32%, n = 5) in terms of relative standard deviation (RSD%). A total of thirty-nine cosmetic samples of different brands and origin

SUBMITTER: Alsohaimi IH 

PROVIDER: S-EPMC7090059 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature