A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging.

ABSTRACT: Lanthanide-doped nanoparticles (LnNPs) have gained increasing attention recently for bioimaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) because of their excellent photophysical properties, but the construction of LnNPs-based activable probe responding to specific targets remains a challenge. Herein, we proposed an uncomplicated and universal strategy to fabricate LnNPs-based NIR-II probes by target-triggered dye-sensitization process. The dye acts as both the recognition motif of the target and a potential antenna for LnNPs, which can be activated by the target to sensitize the NIR-II luminescence of LnNPs. A proof-of-concept probe for glutathione (GSH) was constructed to validate this approach. It was able to track the fluctuation of GSH level in liver and lymphatic dr

SUBMITTER: Li Z 

PROVIDER: S-EPMC7090340 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature