Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells.
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ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC7091176 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells.
Zhou Hui H Qian Qi Q Shu Ting T Xu Jiuyue J Kong Jing J Mu Jingfang J Qiu Yang Y Zhou Xi X
Virologica Sinica 20191127 4
RNAi interference (RNAi) is an evolutionarily conserved post-transcriptional gene silencing mechanism and has been well recognized as an important antiviral immunity in eukaryotes. Numerous viruses have been shown to encode viral suppressors of RNAi (VSRs) to antagonize antiviral RNAi. Hepatitis C virus (HCV) is a medically important human pathogen that causes acute and chronic hepatitis. In this study, we screened all the nonstructural proteins of HCV and found that HCV NS2 could suppress RNAi ...[more]
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