Ontology highlight
ABSTRACT:
SUBMITTER: Fukuma N
PROVIDER: S-EPMC7091505 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20200304 3
Using genetically engineered mice lacking estrogen receptor-α non-nuclear signaling, this study demonstrated that estrogen receptor-α non-nuclear signaling activated myocardial cyclic guanosine monophosphate-dependent protein kinase G and conferred protection against cardiac remodeling induced by pressure overload. This pathway was indispensable to the therapeutic efficacy of cyclic guanosine monophosphate-phosphodiesterase 5 inhibition but not to that of soluble guanylate cyclase stimulation. T ...[more]