The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.

ABSTRACT: The high mannose patch (HMP) of the HIV envelope protein (Env) is the structure most frequently targeted by broadly neutralizing antibodies; therefore, many researchers have attempted to use mimics of this region as a vaccine immunogen. In our previous efforts, vaccinating rabbits with evolved HMP mimic glycopeptides containing Man₉ resulted in an overall antibody response targeting the glycan core and linker rather than the full glycan or Manα1→2Man tips of Man₉ glycans. A possible reason could be processing of our immunogen by host serum mannosidases. We sought to test whether more prolonged dosing could increase the antibody response to intact glycans, possibly by increasing the availability of intact Man₉ to germinal centers. Here, we describe a study i

SUBMITTER: Nguyen DN 

PROVIDER: S-EPMC7091532 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature