Engineered Living Materials Based on Adhesin-Mediated Trapping of Programmable Cells.

ABSTRACT: Engineered living materials have the potential for wide-ranging applications such as biosensing and treatment of diseases. Programmable cells provide the functional basis for living materials; however, their release into the environment raises numerous biosafety concerns. Current designs that limit the release of genetically engineered cells typically involve the fabrication of multilayer hybrid materials with submicrometer porous matrices. Nevertheless the stringent physical barriers limit the diffusion of macromolecules and therefore the repertoire of molecules available for actuation in response to communication signals between cells and their environment. Here, we engineer a novel living material entitled "Platform for Adhesin-mediated Trapping of Cells in Hydrogels" (PATCH). This tech

SUBMITTER: Guo S 

PROVIDER: S-EPMC7091533 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature