Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization.

ABSTRACT: Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effectively rerouting our previously reported α-amination transform.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7091535 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature