Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse.

ABSTRACT: When evaluating the effect of husbandry and biomethodologies on the well-being of laboratory mice, it is critical to utilize measurements that allow the distinguishing of acute stress from chronic stress. One of the most common measurements of stress in laboratory animals is the corticosterone assessment. However, while this measurement provides a highly accurate reflection of the animal's response to acute stressors, its interpretation is more prone to error when evaluating the effect of chronic stress. This study evaluated the use of the neutrophil:lymphocyte (NE:LY) ratio as an assessment of chronic stress in male and female C57Bl/6N mice as compared to serum corticosterone. One group of mice was exposed to mild daily stressors for 7 days, while the control group was handled with normal

SUBMITTER: Hickman DL 

PROVIDER: S-EPMC7091828 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature