Ontology highlight
ABSTRACT:
SUBMITTER: Tsetsarkin KA
PROVIDER: S-EPMC7091890 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nature communications 20140616
Host species-specific fitness landscapes largely determine the outcome of host switching during pathogen emergence. Using chikungunya virus (CHIKV) to study adaptation to a mosquito vector, we evaluated mutations associated with recently evolved sub-lineages. Multiple Aedes albopictus-adaptive fitness peaks became available after CHIKV acquired an initial adaptive (E1-A226V) substitution, permitting rapid lineage diversification observed in nature. All second-step mutations involved replacements ...[more]