Clinical characteristics and risk factors of 47 cases with ruptured neuroblastoma in children.

ABSTRACT:

Background

Neuroblastoma (NB) tumor rupture is a rare oncology emergency with a poor prognosis. We aimed to evaluate patient clinical characteristics and risk factors for ruptured NB.

Methods

A retrospective study of 47 patients with confirmed NB rupture between January 2009 and January 2019 at Beijing Children's Hospital was conducted. To identify tumor rupture risk factors in high-risk NB patients, we included 93 consecutive non-ruptured high-risk NB patients from January 2017 to January 2019.

Results

The median age at presentation was 29 months (adrenal and retroperitoneum origin) for 47 ruptured NB patients. Spontaneous tumor rupture occurred in 22 cases; 18 cases occurred during or after the first chemotherapy cycle, and 7 occurred after core needle biopsy. Five

SUBMITTER: Qin H 

PROVIDER: S-EPMC7092550 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature