Porous gold nanoparticles for attenuating infectivity of influenza A virus.

ABSTRACT:

Background

Influenza viruses (IVs) have become increasingly resistant to antiviral drugs that target neuraminidase and matrix protein 2 due to gene mutations that alter their drug-binding target protein regions. Consequently, almost all recent IV pandemics have exhibited resistance to commercial antiviral vaccines. To overcome this challenge, an antiviral target is needed that is effective regardless of genetic mutations.

Main body

In particular, hemagglutinin (HA), a highly conserved surface protein across many IV strains, could be an effective antiviral target as it mediates binding of IVs with host cell receptors, which is crucial for membrane fusion. HA has 6 disulfide bonds that can easily bind with the surfaces of gold nanoparticles. Herein, we fabricated porous gold n

SUBMITTER: Kim J 

PROVIDER: S-EPMC7092597 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature