Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is a highly lethal malignancy. Improvement in genetic characterization of EOC patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance. Targeted therapies have more efficacy and less toxicity than standard treatments. One of the most relevant cancer-specific actionable targets are protein tyrosine kinases (PTKs) whose role in EOC need to be better investigated.

Methods

EOC genomic datasets are retrieved and analyzed. The biological and clinical significance of RET genomic aberrations in ovarian cancer context are investigated by a series of in vitro and in vivo experiments.

Results

Epithelial ovarian cancer se

SUBMITTER: Guan L 

PROVIDER: S-EPMC7092606 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature