Identification and characterization of the first endogenous phospholipase A₂ inhibitor from a non-venomous tropical snake, Boa constrictor (Serpentes: Boidae).

ABSTRACT:

Background

Endogenous phospholipase A₂ inhibitors from snake blood (sbPLIs) have been isolated from several species around the world, with the primary function of self-protection against the action of toxic phospholipases A_2. In American snakes, sbPLIs were solely described in pit vipers, in which the natural protection role is justified. In this study, we described a sbPLI in Boa constrictor (popularly known as jiboia), a non-venomous snake species from America.

Methods

PLA₂ inhibitory activity was tested in the blood plasma of B. constrictor using C. d. terrificus venom as the enzyme source. Antibodies developed against CNF, a sbγPLI from Crotalus durissus terrificus, were used to investigate the presence

SUBMITTER: Fortes-Dias CL 

PROVIDER: S-EPMC7092641 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature