Personal Fine Particulate Matter Constituents, Increased Systemic Inflammation, and the Role of DNA Hypomethylation.

ABSTRACT: Limited evidence is available on the effects of various fine particulate matter (PM_2.5) components on inflammatory cytokines and DNA methylation. We examined whether 16 PM_2.5 components are associated with changes in four blood biomarkers, that is, tumor necrosis factor-α (TNF-α), soluble cluster of differentiation 40 ligand (sCD40L), soluble intercellular adhesion molecule-1 (sICAM-1), and fibrinogen, as well as their corresponding DNA methylation levels in a panel of 36 healthy college students in Shanghai, China. We used linear mixed-effect models to evaluate the associations, with controls of potential confounders. We further conducted mediation analysis to evaluate the potential mediation effects of components on inflammatory markers through change in DNA methyla

SUBMITTER: Lei X 

PROVIDER: S-EPMC7092684 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature