Vessel-specific quantification of neonatal cerebral venous oxygenation.

ABSTRACT:

Purpose

Noninvasive measurement of cerebral venous oxygenation (Y_v ) in neonates is important in the assessment of brain oxygen extraction and consumption, and may be useful in characterizing brain development and neonatal brain diseases. This study aims to develop a rapid method for vessel-specific measurement of Y_v in neonates.

Methods

We developed a pulse sequence, named accelerated T₂ -relaxation-under-phase-contrast (aTRUPC), which consists of velocity-encoding phase-contrast module to isolate pure blood signal, flow-insensitive T₂ -preparation to quantify blood T₂ , and turbo-field-echo (TFE) scheme for rapid image acquisition, which is critical for neonatal MRI. A series of studies were conducted. First, the pulse

SUBMITTER: Jiang D 

PROVIDER: S-EPMC7092722 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature