Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration.

ABSTRACT: Alzheimer's disease neurodegeneration is thought to spread across anatomically and functionally connected brain regions. However, the precise sequence of spread remains ambiguous. The prevailing model used to guide in vivo human neuroimaging and non-human animal research assumes that Alzheimer's degeneration starts in the entorhinal cortices, before spreading to the temporoparietal cortex. Challenging this model, we previously provided evidence that in vivo markers of neurodegeneration within the nucleus basalis of Meynert (NbM), a subregion of the basal forebrain heavily populated by cortically projecting cholinergic neurons, precedes and predicts entorhinal degeneration. There have been few systematic attempts at directly comparing staging models using in vivo longitudinal biomarker data

SUBMITTER: Fernandez-Cabello S 

PROVIDER: S-EPMC7092749 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature