Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study.

ABSTRACT:

Background

T-wave area dispersion (TW-Ad) is a novel electrocardiographic (ECG) repolarization marker associated with sudden cardiac death. However, limited data is available on the clinical correlates of TW-Ad. In addition, there are no previous studies on cardiovascular drug effects on TW-Ad. In this study, we examined the relation between TW-Ad and left ventricular mass. We also studied the effects of four commonly used antihypertensive drugs on TW-Ad.

Methods

A total of 242 moderately hypertensive males (age, 51±6 years; office systolic/diastolic blood pressure during placebo, 153±14/100±8 mmHg), participating in the GENRES study, were included. Left ventricular mass index was determined by transthoracic echocardiography. Antihypertensive four-week monotherapies (a diure

SUBMITTER: Sanez Tahtisalo H 

PROVIDER: S-EPMC7092984 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature