Thyroid Hormone Effects on Glucose Disposal in Patients With Insulin Receptor Mutations.

ABSTRACT:

Context

Patients with mutations of the insulin receptor gene (INSR) have extreme insulin resistance and are at risk for early morbidity and mortality from diabetes complications. A case report suggested that thyroid hormone could improve glycemia in INSR mutation in part by increasing brown adipose tissue (BAT) activity and volume.

Objective

To determine if thyroid hormone increases tissue glucose uptake and improves hyperglycemia in INSR mutation.

Design

Single-arm, open-label study of liothyronine.

Setting

National Institutes of Health.

Participants

Patients with homozygous (n = 5) or heterozygous (n = 2) INSR mutation.

Intervention

Liothyronine every 8 hours for 2 weeks (n = 7); additional 6 months' treatment in those with hemoglobin A1c (HbA1c

SUBMITTER: Kushchayeva YS 

PROVIDER: S-EPMC7093053 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature