Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels.

ABSTRACT: Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC₅₀ =0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC₅₀ =0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC₅₀ of 0.37 μm. Molecular dynamics simulation studies confirm that th

SUBMITTER: Roy A 

PROVIDER: S-EPMC7093082 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature