Identification of frailty-associated genes by coordination analysis of gene expression.

ABSTRACT: Differential expression analyses provide powerful tools for the identification of genes playing a role in disease pathogenesis. Yet, such approaches are usually restricted by the high variation in expression profiles when primary specimens are analyzed. It is conceivable that with the assessment of the degree of coordination in gene expression as opposed to the magnitude of differential expression, we may obtain hints underscoring different biological and pathological states. Here we have analyzed a publicly available dataset related to frailty, a syndrome characterized by reduced responsiveness to stressors and exhibiting increased prevalence in the elderly. We evaluated the transcriptome that loses its coordination between the frailty and control groups and assessed the biological functi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7093164 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature